Niobium txhim kho corrosion kuj thiab biocompatibility ntawm implants

Raws li thaum ntxov xyoo 1991, kev tshawb fawb thiab kev soj ntsuam ntawm cov titanium ntshiab implants thiab ntshiab niobium implants implanted nyob rau hauv luav pob txha pom tau hais tias qhov qhib torque ntawm ntshiab niobium implants yog ho siab dua li cov ntshiab titanium implants, thiab nws twb speculated tias qhov no tej zaum yuav yog vim li cas. qhov tsis sib xws ntau qhov chaw morphology ntawm ntshiab niobium implants piv rau cov ntshiab titanium cog. Txawm li cas los xij, kev tshawb fawb ntxiv tau ua tiav ntawm kev qhia txog niobium rau hauv titanium alloys los txo cov nag lossis daus ntawm cov hlau lom (xws li, npib tsib xee, vanadium) ions los ntawm titanium alloys los txhim kho biocompatibility ntawm titanium alloys, thiab txo cov modulus ntawm elasticity. ntawm titanium alloys thiab kom cov neeg kho tshuab lub zog ntawm implants.Sakai li al. tshuaj xyuas cov teebmeem ntawm 15 feem ntau siv biomaterials ntawm bioactivity ntawm osteoclast-zoo li cov hlwb thiab pom tias vanadium thiab vanadium, nyob rau hauv ob qho tib si particulate thiab ionic daim ntawv, muaj ho qhib torque ntau dua li ntshiab titanium implants. thiab cov ntaub ntawv ionic, vanadium thiab npib tsib xee tau cytotoxic ntau dua li niobium.

Park et al. piv rau cytocompatibility ntawm cov hlau ntshiab thiab binary titanium alloys rau implantation, thiab qhov nruab nrab cytocompatibility ntawm txhuas, vanadium, thiab niobium yog 25.3%, 31.7%, thiab 93%, feem. Ntawm cov hlau ntshiab, ntshiab titanium yog cov cytocompatible tshaj plaws (thiab qhov tsawg tshaj plaws cytotoxic), tab sis Ti-lONb alloys pom cytocompatibility uas tshaj cov ntshiab titanium, nrog ib tug nruab nrab cytocompatibility ntawm 124.8%.D.1 igima li al. qhia tau tias Ti-6AI-7Nb alloy tau zoo dua hnav tsis kam thiab txhua yam muaj zog dua li titanium ntshiab.Yoshimitsu li al. implanted implants ua los ntawm Ti-1 5Zr-4Nb-4Ta alloy thiab Ti-6A1-4V alloy rau hauv nas tibia feem thiab tua lawv tom qab 48 lub lis piam, uas qhia tau hais tias qhov chaw ntawm Ti-15Zr-4Nb-4Ta implant muaj Cov txiaj ntsig tau pom tias cov pits corrosion nyob rau saum npoo ntawm Ti-15Zr{{21 }}Nb-4Ta implant tsawg dua cov nyob rau saum npoo ntawm Ti-6Al-4V implant, qhia tau hais tias qhov corrosion kuj ntawm lub qub yog muaj zog tshaj qhov tom kawg.

Chaw et al. piv cov cytotoxicity thiab cellular teb ntawm osteogenic precursor hlwb nrog cov Ti-6A1-7Nb alloy thiab Ti-6A1-4V alloy, thiab cov txiaj ntsig tau pom tias Ti{ {4}}A1-7Nb implants tau siab dua Ti-6Al-4V implants nyob rau hauv cov nqe lus ntawm cellular adhesion, proliferation, viability, morphology, thiab extension. Tsis tas li ntawd, kev tshuaj ntsuam xyuas immunofluorescence tau qhia txog kev nthuav qhia ntawm cell adhesion proteins thiab txuas ntxiv ntawm actin nro fibers hauv thaj tsam extracellular ntawm Ti-6Al-7Nb alloy.Stenlund li al. muab piv rau hauv vivo cov txiaj ntsig ntawm Ti-Ta-Nb-Zr alloy cog tshiab nrog cov ntshiab titanium, thiab pom tias cov niobium-muaj alloy tshiab tau ua tiav cov ntshiab titanium alloy nyob rau hauv cov nqe lus ntawm kev cog qoob loo ntev thiab ceev ntawm cov pob txha kho. , thiab nyob rau hauv cov nqe lus ntawm osteointegration muaj peev xwm. Takahashi et al. piv rau biomechanical zog ntawm qis modulus elasticity Ti-Nb-Sn alloy nrog cov ntshiab titanium implants thiab pom tias cov biomechanical zog ntawm cov alloys muaj peev xwm ua tau raws li qhov xav tau ntawm osseointegration.

Kev kawm ntawm Han Xue et al. pom tias micro-arc oxidized alkali tshav kub-kho Ti-24Nb-4Zr-7.9Sn alloy implant tuaj yeem tsim ib qho zoo osseointegration nrog Bio-Oss thiab nws nyob ib puag ncig nascent osteoid, coj regeneration ntawm pob txha cov ntaub so ntswg.